Clinical observation of tinidazole combined with minocycline hydrochloride ointment and root canal therapy on periodontal-endodontic lesions

Abstract

Objective To observe the effect of tinidazole, minocycline hydrochloride ointment combined with root canal therapy on periodontal-endodontic lesions. Methods Ninety-nine patients with periodontal-endodontic lesions were selected and randomly divided into two groups. Forty-nine patients in the control group were treated by root canal therapy and took tinidazole orally after the operation; 50 patients in the observation group were treated with minocycline and hydrochloride ointment based on the treatment of the control group. The clinical therapeutic effects, the changes of gingival bleeding index (BI), plaque index (PLI), gingival index (GI), bleeding index (BOP), periodontal probing depth (PD) before and after treatment of the two groups were observed and compared. The adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 96.00% (48/50), which was higher than that of the control group [77.55% (38/49)], and the difference was statistically significant (P 0.05). Conclusions Tinidazole combined with minocycline hydrochloride and root canal therapy can improve the bleeding index, plaque index, gingival index, exploration bleeding index and periodontal exploration depth in periodontal pulpitis patients, with the advantages of high curative effect and high safety. Key words: Root canal therapy; Minocycline hydrochloride ointment; Tinidazole; Combined periodontal-endodontic lesions