Clinical observation of thalidomide combined with mFOLFOX in the treatment of advanced colon cancer

Abstract

Objective To discuss the efficiency and safety of thalidomide combined with mFOLFOX in treating advanced colon cancer.In addition,to observe the influence of m FOLFOX combined with thalidomide on serum vascular endothelial growth factor(VEGF)leveles. Methods One hundred patients with advanced colon cancer were divided randomly into two groups by digital table method.In the combined group,fifty patients were treated by mFOLFOX combined with thalidomide.In the control group,fifty patients were treated by mFOLFOX alone. All the patients were tested serum VEGF before and after four cycle of chemotherapy. Results The response rate was 42% in the combined group vs.38% in the control group.Higher clinical benefit rate was found in the combined group (78% vs.68%).The median time to progression(TTP) was 110 days vs.107 days.The differents between the two groups were not statistically significant(all P> 0.05).After treatment of 4 cycles,the serum VEGF concentration of combined group and control group were respectively(317.40±55.54)ng/L and(330.84±64.48)ng/L,which were significantly decreased compared with pretreafment.The combination group decreased more obviously,the difference between the two groups were statistical significance(t= 11.634,P= 0.000). Conclusion Combined thalidomide with mFOLFOX can't improved clinical curative effect on the advanced colon cancer significantly.However,thalidomide can reduce the levels of serum VEGF,and improve the quality of life. Key words: Anti tumor chemotherapy regimen; Combined; Colon neoplasms; Thalidomide