Clinical observation of photodynamic therapy for choroidal neovascularization secondary to pathological myopia

Abstract

Objective To observe the efficacy of photodynamic therapy (PDT) for choroidal neovascularization (CNV) secondary to pathological myopia (PM).Methods Sixty-six patients (73 eyes)with CNV secondary to PM who had undergone PDT were enrolled in this study.PDT was performed according to the standard treatment.The patients received the examinations of best corrected visual acuity (BCVA),ophthalmoscopy,fundus fluorescein angiography (FFA) and/or indocyanine green angiography (ICGA),and optical coherence tomography (OCT) before and after the treatment.Vision results were converted into logMAR records and compared before and after the treatment.The complete records of FFA were found in 52 eyes.FFA findings,treatment effects,were judged as well,moderate or poor according to the CNV leakage or bleeding,and CNV expanding or shrinking.The complete records of OCT were found in 11 eyes.CNV regional edema and foveal thickness were analyzed based on OCT examination.Results The mean logMAR BCVA after PDT treatment was 0.74 ± 0.51 with no significant difference compared with before treatment (t=1.11,P=0.27).There were 18 eyes (24.7％) with improved vision,43 eyes (58.9 ％ ) with stable vision,and 12 eyes (16.4 ％ ) with decreased vision.In 52 eyes with FFA findings,39 eyes (75.0％) with well effect,9 eyes (17.1％) with moderate effect,and 4 eyes (7.7％) with poor effect.OCT showed that after treatment the CNV regional edema subsided in most of eyes,and there were 7 (63.64％) with decreased foveal thickness,2 (18.18％) with stable thickness,and 2 (18.18％) with increased thickness.Conclusions PDT is an effective treatment for CNV secondary to PM.It may improve or stabilize the visual acuity. Key words: Choroidal neovascularization/therapy; Photochemotherapy; Myopia; degenerative/complications