Clinical observation of photodynamic therapy for choroidal neovascularization disease

Abstract

Objective To evaluate the clinical efficacy and safety of photodynamic therapy (PDT) for choroidal neovascularization (CNV).Methods A retrospective analysis from September 2010 to June 2012 using verteporfin photodynamic therapy (PDT) for treatment of choroidal neovascularization disease in 50 cases 65 eyes.Clinical effect,vision,CNV range,optical coherence tomography (OCT),Fluorescein angiography (FFA),indocyanine green angiography (ICGA) such as image PDT data before and after treatment were compared.Age-related macular degeneration (AMD) was 50 eyes in 35 cases; Central exudative chorioretinopathy (CEC) 5 eyes in 5 cases; Polypoidal choroidal vasculopathy (PCV) 4 eyes in 4 cases; pathologic myopia (PM) 5 eyes in 5 cases; Traumatic choroidal rupture CNV 1 eye in 1 case.Results Sixty-five eyes of 50 patients underwent PDT with 6 months follow-up.Visual Acuity (VA) kept stability and improved 30 eyes (69.76％) in AMD,4 eyes (80.00％) in CEC,2 eyes (50.00％) in PCV,4 eyes (80.00％) in PM,1 eye (100％) in choroid crack CNV.The CNV leakage was observed 20 eyes (46.51％) in AMD,1 eye (20.00％) in CEC,2 eyes (50.00％) in PCV,1 eye (20.00％) in PM.There were 30 recurrence eyes in 30 cases according to ICGA,and FFA examination,including 10 eyes in 10 cases with the second time retreatment and 3 eyes in 3 cases with third time retreatment.There was difference from the period of retreatment:1 eye in 1 case at the time of one month post treatment,5 eyes in 5 cases 3 months after treatment,and 1 eye in 1 case post treatment.All cases were no occurred severe complications.Conclusions PDT is a safe and effective treatment for patients of CNV caused by different macular disease,which can reduce CNV leakage,delay visual acuity decrease,however still needs re-treatment. Key words: Photodynamic therapy; Choroidal neovascularization