Clinical observation of lacrimal duct intubation with mitomycin and TobraDex Ophthalmic ointment in the treatment of lacrimal passage obstruction

Abstract

Objective To observe the lacrimal intubation with mitomycin and TobraDex Ophthalmic ointment (TDO) in the treatment of lacrimal passage obstruction.Methods Senventy-eight eyes with obstruction of lacrimal passage were randomly divided into group A (40 eyes,MMC+TDO)and group B (38 eyes,control group).In group A,40 eyes firstly applied 0.2mg/ml MMC,washed thoroughly after 5 minutes,then filled up TobraDex Ophthalmic ointment.In group B,38 eyes only conducted Lacrimal duct intubation.Results All patients were followed up for 6-9 months.After 1 month and 3 months treatment,the healing rates of group A were 100％,group B 89.5％,81.5％respectively; after 3 and 9 months,the healing rates of group A were 95％,group B was 73.7％,71.1％ respectively,there was a great significantly difference between the two groups (P ＜0.05),group A was significantly higher than that of B group.Conclusions Mitomycin C combined with TobraDex Ophthalmic ointment can significantly improve the healing rate on patients of LDCL in long term. Key words: Lacrimal passage obstruction; Duct intubation; Mitomycin C; TobraDex Ophthalmic ointment