Clinical observation of Ganciclovir ophthalmic gel in the treatment of viral keratitis

Abstract

Objective To evaluate the curative effect of 0.15% Ganciclovir ophthalmic gel in the treatment of Herpes Simplex Keratitis and Herpes Zoster Keratitis.Methods Randomly,40 cases of Herpes Simplex Keratitis were divided into two groups,20 cases were given 0.15% Ganciclovir ophthalmic gel four times per day,the others 20 cases were given 0.1% Acyclovir eyedrop four times per day as Also,30 cases of Herpes Zoster Keratitis were divided into two groups.15 were given 0.15% Ganciclovir ophthalmic gel four times per day,the others were given 0.1% Acyclovir eyedrop four times per day.The symptoms and signs were observed at the first visit to doctor,and the changes were recorded at the 3,7 and 14 days after treatment,respectively.Results After 3,7 and 14 days'treatment,the scores of symptoms and signs of the test groups were significantly reduced(Wilcoxon rank sum test,P＜0.05).compared to th control groups,the declining values of the score of the symptoms which includes ophthalmalgia,photophobia,lacrimation,and foreign body sensation and the signs of comeal infiltration of test groups were significantly statistical difference(F test,P＜0.05).When the effect power of the Ganciclovir groups in HSK were 95.0% and 93.3% in HZK.White the 0.1% Acyclovir eyedrop's groups were 80.0%,and both in HSH and HZK.The difference between the 2 groups had statistical significance(Ridit test,P＜0.05).Conclusions The 0.15% Ganciclovir ophthalmic gel has better curative effect than 0.1% Acyclovir eyedrop in the treatment of viral keratitis. Key words: Herpes simplex virus; Herpes zoster virus; Ganciclovir ophthalmic gel