Clinical observation of different concentration allocation ratios applied to phlebitis caused by levofloxacin hydrochloride by intravenous infusion

Abstract

Objective To investigate the condition of different concentration allocation ratios applied to phlebitis caused by levofloxacin hydrochloride by intravenous infusion. Methods Prospective study was conducted to 400 patients with levofloxacin hydrochloride by intravenous infusion. According to doctor's prescription, liquid medicines at different concentration ratios were made and divided into observation group (100 cases), control group 1 (100 cases), control group 2 (100 cases) and control group 3 (100 cases). 0.3 g levofloxacin hydrochloride and 0.9% NaCl solution were used to prepare liquid medicine for the patients in 4 groups. The liquid medicine concentration allocation ratios of observation and control groups 1, 2 and 3 were 0.1 g∶50 ml, 0.1 g∶75 ml, 0.1 g∶100 ml, 0.1 g∶125 ml . The occurrence of phlebitis of patients in 4 groups was observed. Results Observation group was compared with control groups 1, 2 and 3. The result was χ2=4.35, P<0.05; χ2=7.04, P<0.05; χ2=23.95, P<0.01, both differences were statistically significant. Conclusion The concentration allocation ratio of 0.1 g: 50 ml can effectively prevent or reduce the occurrence rate of phlebitis caused by levofloxacin hydrochloride by intravenous infusion. Key words: Levofloxacin; Phlebitis; Solution concentration