Clinical observation of continuous compress with multiple drugs mixed in the treatment of skin lesions caused by chemotherapeutic drugs extravasation

Abstract

Objective To explore the effects of continuous compress with multiple drugs mixed in the treatment of skin lesions caused by chemotherapeutic drugs extravasation.Methods Totals of 32 cases of cancer applied peripheral superficial vein chemotherapy and occurred drugs extravasation from Jan.2009 to Dec.2010 as control group,lidocaine 100 mg,dexamethasone 3 mg and saline 5 ml were used through circular hypodermic injection around the point of puncture;Totals of 33 cases applied peripheral superficial vein chemotherapy and occurred drugs extravasation from Jan.2011 to Jun.2012 as treatment group,in addition to the therapeutic methods mentioned above,local continuous compress with gauze soaked by multiple drugs (50％ magnesium sulfate,2％ lidocaine,dexamethasone,5％ sodium bicarbonate,anisodamine,vitamin B12,saline) mixed were implemented.Results The treatment group had a higher overall response rate(100.0％),and more effective rate(75.8％),with the control group overall response rate(78.1％),and more effective rate(46.9％),and the difference was statistically significant (x2 =5.97,5.73,respectively;P ＜ 0.05).The cases of swelling disappeared within 24 hours of treatment group was significantly more than that of control group(16 vs 7),while the cases of swelling disappeared within 73-120 hours of treatment group was significantly less than that of control group(4 vs 12),with significant difference(x2 =5.03,5.64;P ＜ 0.05).Conclusions On the base of using lidocaine to cure skin lesions caused by chemotherapeutic drugs extravasation,continuous compress with gauze soaked by multiple drugs mixed is an effective therapy. Key words: Extravasation of diagnostic and therapeutic materials; Chemotherapy drug; Skin lesion; Multiple drugs mixture; Continuous compress