Clinical observation of Amoxicillin Sodium and Clavulanate Potassium combined with chemotherapy in treating new pulmonary tuberculosis

Abstract

Objective To study the efficacy and adverse reaction of Amoxicillin Sodium and Clavulanate Potassium in treating new smear positive tuberculosis (TB).Methods One hundred and nine new smear positive pulmonary TB patients were randomly divided into treatment group,who received Amoxicillin Sodium and Clavulanate Potassium + 2HRZE/4HR (58 cases ) and control group,who received 2HRZE/4HR(51 cases).Results The sputum negative conversion rate at the third week,the first and second month were 44.8％,62.0％,89.7％ in the treatment group and 25.5％,41.2％,76％ in the control group respectively,at the second month chest radiography showed the resolution of pulmonary lesions in the treatment group and control group were 37.9％ and 19.6％ respectively,with cavity closure rate of 65.5％ in the treatment group and 38.7％ in the control group,at third week,the clinical symptoms such as cough,fever,fatigue disappeared at the levels of 48.3％,71.4％,59.3％ in the treatment group and 25.5％,50.0％,40.0％ in the control group (P ＜0.05),there was no drug adverse reaction in the treatment group,there was no significant difference in the sputum positive conversion rate at the 6,12 month after treatment between the treatment group and the control group (P ＞ 0.05 ).Conclusions Amoxicillin Sodium and Clavulanate Potassium combined with chemotherapy shortens the time of sputum negative conversion,the resolution of pulmonary lesions and the improvement of clinical symptoms.The drug adverse reaction is little.It is a fairly good immune drug for TB treatment and is worth to be recommended. Key words: Tuberculosis; Drug therapy; Amoxicillin Sodium and Clavulanate Potassium