Clinical impacts of kallidinogenase on renal functionin early diabetic kidney disease

Abstract

Objective To investigate the impact of kallidinogenase on renal function in early diabetic kidney dis-ease. Methods Forty - six cases of patients suffered from type 2 diabetes mellitus were divided into two groups at random in which 26 cases served as observed group accepted kallidinogenasemedicationadditionally and the other 20 cases received comprehensive medication simultaneously. Fasting blood glucose, 2 hours postprandial blood glucose, glycosylated serum protein, total cholesterol, triglycerides, blood pressure, items of hemurheology, 24 - hour urine protein, time span of peak time, residual rate for 10 minutes and 15 minutes were record and compared before and after three cases of medication. Re-sults Indexes of hemorheoiogy decreased significantly after 3 causes of medication (P < 0. 01), blood lipid, and blood pressure also declined significantly(P <0.01). 15 minutes residual rate decreased significantly and I0 minutes residual rate also declined(P < 0. 01). The 24 - hour urinary protein reduced significantly(P < 0.01). Conclusions Kallidino-genase can effectively decrease blood viscosity and platelet aggregation, lowering blood lipids and blood pressure, improving the secretion and excretion function, reducing the discharge of urine protein and promote the resumption of diabetic kidney disease in early stage. Key words: Renal function; Kallidinogenase; Diabetes mellitus; Early diabetic kidney disease