Abstract
The aim of the study was to examine the structure of psychopathology and clinical features of depressive disorders in patients with brain oncopathology. Polymorphic mental disorders of various clinical content and severity in most cases not only are comorbid to oncological pathology of the brain, but most often are the first clinical signs of early tumors. The study was conducted using the following methods: clinical psychiatric, questionnaire Simptom Check List- 90 -Revised-SCL- 90 -R, Luscher test and mathematical processing methods. Sample included 175 patients with brain tumors with non-psychotic level of mental disorders. The peculiarities of mental disorders and psychopathological structure of nonpsychotic depressive disorders have been a clinical option of cancer debut in patients with brain tumors. We found that nonpsychotic depression is characterized by polymorphism and syndromal incompletion; this causes ambiguity of diagnoses interpretation on stages of diagnostic period. Features of depressive symptoms depending on the signs of malignancy / nonmalignancy of brain tumor were defined.
Highlights
Ɉɪɨɛɥɟɦɚ ɜɡɚɢɦɨɡɚɜɢɫɢɦɨɫɬɢ ɦɟɠɞɭ ɨɧɤɨɥɨɝɢɱɟɫɤɢɦɢ ɡɚɛɨɥɟɜɚɧɢɹɦɢ ɢ ɩɫɢɯɢɱɟɫɤɢɦɢ ɪɚɫɫɬɪɨɣɫɬɜɚɦɢ, ɜɥɢɹɸɳɢɦɢ ɧɚ ɬɹɠɟɫɬɶ ɫɨɫɬɨɹɧɢɹ, ɫɬɟɩɟɧɶ ɞɟɡɚɞɚɩɬɚɰɢɢ, ɤɨɦɩɥɚɟɧɬɧɨɫɬɶ ɤ ɬɪɚɞɢɰɢɨɧɧɵɦ ɦɟɬɨɞɚɦ ɥɟɱɟɧɢɹ ɢ ɩɪɨɞɨɥɠɢɬɟɥɶɧɨɫɬɶ ɠɢɡɧɢ ɛɨɥɶɧɵɯ, ɡɚɬɪɚɝɢɜɚɟɬɫɹ ɦɧɨɝɢɦɢ ɢɫɫɥɟɞɨɜɚɬɟɥɹɦɢ [1, 2, 4]. ɉɨɥɢɦɨɪɮɧɵɟ ɩɫɢɯɢɱɟɫɤɢɟ ɧɚɪɭɲɟɧɢɹ ɪɚɡɥɢɱɧɨɝɨ ɤɥɢɧɢɱɟɫɤɨɝɨ ɫɨɞɟɪɠɚɧɢɹ ɢ ɫɬɟɩɟɧɢ ɜɵɪɚɠɟɧɧɨɫɬɢ ɧɟ ɬɨɥɶɤɨ ɜ ɛɨɥɶɲɢɧɫɬɜɟ ɫɥɭɱɚɟɜ ɤɨɦɨɪɛɢɞɧɵ ɨɧɤɨɥɨɝɢɱɟɫɤɨɣ ɩɚɬɨɥɨɝɢɢ ɝɨɥɨɜɧɨɝɨ ɦɨɡɝɚ, ɧɨ ɢ ɡɚɱɚɫɬɭɸ ɹɜɥɹɸɬɫɹ ɩɟɪɜɵɦɢ ɧɚɢɛɨɥɟɟ ɪɚɧɧɢɦɢ ɤɥɢɧɢɱɟɫɤɢɦɢ ɩɪɨɹɜɥɟɧɢɹɦɢ ɧɨɜɨɨɛɪɚɡɨɜɚɧɢɣ
We found that nonpsychotic depression is characterized by polymorphism and syndromal incompletion; this causes ambiguity of diagnoses interpretation on stages of diagnostic period
Ȼ ɫɬɪɭɤɬɭɪɟ ɬɪɟɜɨɠɧɵɯ ɫɨɫɬɨɹɧɢɣ ɩɪɢ ȾɇɈ ɩɪɟɨɛɥɚɞɚɥ ɮɨɛɢɱɟɫɤɢɣ ɤɨɦɩɨɧɟɧɬ (32,5%), ɧɚ ɜɬɨɪɨɦ ɦɟɫɬɟ ɩɨ ɱɚɫɬɨɬɟ ɨɬɦɟɱɟɧɵ ɬɪɟɜɨɠɧɵɟ ɫɨɫɬɨɹɧɢɹ ɫ ɫɟɧɟɫɬɨɩɚɬɢɹɦɢ (29,3%); ɬɪɟɜɨɠɧɵɟ ɧɚɪɭɲɟɧɢɹ ɫ ɞɟɩɟɪɫɨɧɚɥɢɡɚɰɢɨɧɧɨ-ɞɟɪɟɚɥɢɡɚɰɢɨɧɧɵɦ ɢ ɢɩɨɯɨɧɞɪɢɱɟɫɤɢɦ ɤɨɦɩɨɧɟɧɬɚɦɢ ɫɨɫɬɚɜɢɥɢ 20,5% ɢ 18,0% ɧɚɛɥɸɞɟɧɢɣ ɫɨɨɬɜɟɬɫɬɜɟɧɧɨ
Summary
Ɉɪɨɛɥɟɦɚ ɜɡɚɢɦɨɡɚɜɢɫɢɦɨɫɬɢ ɦɟɠɞɭ ɨɧɤɨɥɨɝɢɱɟɫɤɢɦɢ ɡɚɛɨɥɟɜɚɧɢɹɦɢ ɢ ɩɫɢɯɢɱɟɫɤɢɦɢ ɪɚɫɫɬɪɨɣɫɬɜɚɦɢ, ɜɥɢɹɸɳɢɦɢ ɧɚ ɬɹɠɟɫɬɶ ɫɨɫɬɨɹɧɢɹ, ɫɬɟɩɟɧɶ ɞɟɡɚɞɚɩɬɚɰɢɢ, ɤɨɦɩɥɚɟɧɬɧɨɫɬɶ ɤ ɬɪɚɞɢɰɢɨɧɧɵɦ ɦɟɬɨɞɚɦ ɥɟɱɟɧɢɹ ɢ ɩɪɨɞɨɥɠɢɬɟɥɶɧɨɫɬɶ ɠɢɡɧɢ ɛɨɥɶɧɵɯ, ɡɚɬɪɚɝɢɜɚɟɬɫɹ ɦɧɨɝɢɦɢ ɢɫɫɥɟɞɨɜɚɬɟɥɹɦɢ [1, 2, 4]. ɉɨɥɢɦɨɪɮɧɵɟ ɩɫɢɯɢɱɟɫɤɢɟ ɧɚɪɭɲɟɧɢɹ ɪɚɡɥɢɱɧɨɝɨ ɤɥɢɧɢɱɟɫɤɨɝɨ ɫɨɞɟɪɠɚɧɢɹ ɢ ɫɬɟɩɟɧɢ ɜɵɪɚɠɟɧɧɨɫɬɢ ɧɟ ɬɨɥɶɤɨ ɜ ɛɨɥɶɲɢɧɫɬɜɟ ɫɥɭɱɚɟɜ ɤɨɦɨɪɛɢɞɧɵ ɨɧɤɨɥɨɝɢɱɟɫɤɨɣ ɩɚɬɨɥɨɝɢɢ ɝɨɥɨɜɧɨɝɨ ɦɨɡɝɚ, ɧɨ ɢ ɡɚɱɚɫɬɭɸ ɹɜɥɹɸɬɫɹ ɩɟɪɜɵɦɢ ɧɚɢɛɨɥɟɟ ɪɚɧɧɢɦɢ ɤɥɢɧɢɱɟɫɤɢɦɢ ɩɪɨɹɜɥɟɧɢɹɦɢ ɧɨɜɨɨɛɪɚɡɨɜɚɧɢɣ. Ɋɚɫɫɦɨɬɪɟɧɵ ɨɫɨɛɟɧɧɨɫɬɢ ɩɫɢɯɢɱɟɫɤɢɯ ɧɚɪɭɲɟɧɢɣ ɢ ɩɫɢɯɨɩɚɬɨɥɨɝɢɱɟɫɤɚɹ ɫɬɪɭɤɬɭɪɚ ɞɟɩɪɟɫɫɢɜɧɵɯ ɪɚɫɫɬɪɨɣɫɬɜ ɧɟɩɫɢɯɨɬɢɱɟɫɤɨɝɨ ɭɪɨɜɧɹ, ɹɜɢɜɲɢɯɫɹ ɤɥɢɧɢɱɟɫɤɢɦ ɜɚɪɢɚɧɬɨɦ ɞɟɛɸɬɚ ɨɩɭɯɨɥɟɜɨɝɨ ɩɪɨɰɟɫɫɚ ɭ ɛɨɥɶɧɵɯ ɫ ɨɩɭɯɨɥɹɦɢ ɝɨɥɨɜɧɨɝɨ ɦɨɡɝɚ. Ɐɟɥɶɸ ɢɫɫɥɟɞɨɜɚɧɢɹ ɛɵɥɨ ɢɡɭɱɢɬɶ ɩɫɢɯɨɩɚɬɨɥɨɝɢɱɟɫɤɭɸ ɫɬɪɭɤɬɭɪɭ ɢ ɤɥɢɧɢɱɟɫɤɢɟ ɨɫɨɛɟɧɧɨɫɬɢ ɞɟɩɪɟɫɫɢɜɧɵɯ ɪɚɫɫɬɪɨɣɫɬɜ ɭ ɛɨɥɶɧɵɯ ɫ ɨɧɤɨɥɨɝɢɱɟɫɤɨɣ ɩɚɬɨɥɨɝɢɟɣ ɝɨɥɨɜɧɨɝɨ ɦɨɡɝɚ.
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