Clinical features of 75 cases with hand-foot-and-mouth disease

Abstract

Objective The purpose of this study was to help diagnose severe Hand-foot-and-mouth disease (HFMD) cases at early stage. Methods This research employed a retrospective analysis approach and analyzed a number of severe HFMD cases based on the clinical records. Results The results showed that 86. 7% of severe HFMD cases happened among infants under the age of three,and there were more boys than girls; patients' conditions tended to deteriorate within one to five days after its outbreak,the rashes were not typical,and they were mostly small and few,sometimes none,the complications mostly concerned the nervous system and clinically manifested as Meningitis, brain stem encephalitis,acute flaccid paralysis,and neurogenic pulmonary edema etc. at the early stage of HFMD, 73. 3% of the cases involved symptoms of quivering of the pantomimes or hyperarousal,69. 3% of the cases showed listlessness,coma,or fidget,37. 3% of the cases invloved increase of peripheral cytometry,30.0% of the cases involved vomiting,20. 0% involved rising of respiration and cardiac rates, 15. 0% involved eclampsia, 10.0% involved coldness of the four limbs,6.5% involved constant high fever. The analysis showed that at the early stage of the disease, methylprednisolone and megadoses of IVIC could effectively contain .patients' conditions, and the cure rate reached as high as 93. 3%. Conclusions Complications concerning the nervous system usually happened to severe HFMD infected infants. Once there was early-stage clinical symptoms of nervous complications, and appropiate doses of adrenal cortical hormone and IVIG intervention could effectively block or defer the conditions. Key words: Hand,foot and mouth disease; Methylprednisolone; Immunoglobulins,intravenous