Abstract
Abstract. Sixty‐one necrokidneys have been preserved by means of hypothermic storage following a short initial cooling perfusion with a perfusate which mimics the intracellular ion composition. Five kidneys failed to function due to acute vascular rejection, but the remaining 56 functioned satisfactorily at some time after transplantation, the criterion being that the lowest obtained serum creatinine in the recipient reached normal or nearly normal values. Fifty‐seven kidneys originated from neurosurgical donors, in whom assisted respiration was stopped after demonstration of brain death and from whom the kidneys were removed after cardiac arrest. Four kidneys originated from donors with sudden cardiac arrest. The kidneys from the neurosurgical donors were divided into two groups according to pretreatment of the donor with chlorpromazine. In group 1 (26 kidneys) no chlorpromazine was given and in group 2 (31 kidneys) chlorpromazine 4 mg/kg b.wt. was given just before stopping the assisted ventilation. The pretreatment with chlorpromazine increased the number of immediately functioning kidneys after transplantation from 56 to 85% and, since the two groups were almost similar with respect to factors which may influence the postoperative kidney function, it is concluded that the difference derives from the use of chlorpromazine. No difference in the best achieved kidney function could be demonstrated between the two groups. Six kidneys had a cold ischaemic time between 14 and 21 hours (group 3). All these kidneys functioned after transplantation, and normal or nearly normal serum creatinine values were obtained in the recipients.
Published Version
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