Abstract
NORMAL human urine contains measurable amounts of the adrenal cortical hormone which promotes gluconeogenesis and which, by promoting the conversion of body protein to carbohydrate, maintains the blood glucose and liver glycogen levels in the fasting state. In 1942 Reinecke and Kendall (1) published a method for the bioassay of this adrenal cortical hormone which made use of the rapid loss of liver glycogen in the fasted adrenalectomized rat as compared with the adrenalectomized animal treated with adrenal cortical extract. This method was modified and adapted to the mouse and used for testing urinary extracts in clinical investigation by Eggleston, Johnston and Dobriner (2), Venning, Kazmin and Bell (3) and Dorfman, Ross and Shipley (4). The method used in this laboratory is that of Eggleston, Johnston and Dobriner with a few minor changes. A comparison of the techniques used and the results obtained with these methods is given in detail in the Transactions of the Tenth Conference on Metabolic Aspects of...
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