Abstract
The use of moisturizers improves the skin barrier’s function and might be useful in atopic dermatitis. Objectives: To assess the efficacy and safety of an active moisturizer-barrier repairer based on glycerin, erythritol, Imperata cylindrica and homarine as an adjuvant treatment in atopic dermatitis. Methods: Application of the moisturizer in children with mild to moderate atopic dermatitis for 1 month, with subjective and objective evaluations after 15 and 30 days. Results: Data from 35 children – 20 girls (57.15%), 15 boys (42.86%) / 26 Caucasians (74.29%), 6 mulattos (17.14%), 3 dark skinned (8.57%) – aged 1 to 10 years (mean age = 5.6) were analyzed. The values of the variables sleeping disorders, dryness, desquamation, pruritus and softness of the skin had significantly decreased on the 30th day of treatment as compared to the baseline. The objective evaluation of the severity using the Scoring Atopic Dermatitis severity index revealed a decrease to 9.30 from 25.27 (p <0.0001). There was a reduction in the use of dexchlorpheniramine and hydrocortisone to 5.72% each on the 30th day, from 25.71% (p = 0.0233) and 34.29% (p = 0.0075) on the 15th day, respectively. Conclusions: The use of the moisturizer for 30 days improved the analyzed symptoms with a significant reduction in the Scoring Atopic Dermatitis severity index with decreased need for antihistamines and topical corticosteroids. The use of a suitable moisturizer was effective and safe as an adjuvant treatment for children with atopic dermatitis
Highlights
The use of moisturizers improves the skin barrier’s function and might be useful in atopic dermatitis
Atopic dermatitis (AD) is a chronic, recurrent and pruriginous inflammatory skin disease resulting from a complex interdependence of genetic, immunological, and environmental factors.[1]
The authors of the present study investigated the effects of a formulation containing moisturizing ingredients, lipid components, and botanical active principles with osmoregulatory properties (Imperata cylindrica and homarine) for reducing the severity of the lesions, relieving pruritus, and improving cutaneous hydration, sleeping disorders and tolerability in pediatric patients with mild to moderate AD
Summary
The use of moisturizers improves the skin barrier’s function and might be useful in atopic dermatitis. It is estimated that 50% of new cases occur in the first year of life, with 85% of cases beginning before the age of five It is the most important chronic dermatologic disease in this age group.[1] The cardinal symptom of AD is pruritus, even in infants and young children, leading to restlessness or difficulty to fall asleep. Xerosis is another frequent sign in AD, resulting from several alterations in barrier function, such as increased transepidermal water loss, decreased ceramides 1 and 3, decreased fatty acids and cholesterol in the skin. Eczematous lesions vary according to the age group, being predominantly acute up to two years of age, subacute up until puberty and chronic in adults, with surges at any time of life.[1]
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