Abstract
New generations of hematology analyzers produce fast and reliable data on blood count, while at the same time offering screening information on differential blood count. The aim of this study was to evaluate a Cell-Dyn® (CD) 1700CS (Abbott Diagnostics, Abbott Park, IL) hematology analyzer that determines 18 parameters, including three-part differential blood count. A single unit instrument consists of a sample analyzer, data module section, and printer as a separate component. The analyzer contains the hardware to aspirate, dilute, and analyze each whole-blood sample from open and closed collection tubes or prediluted samples. Aspiration volume in open mode is 30 μL, in closed mode 450 μL, and in predilute mode 40 μL. The data module section includes a computer controlling all operations and storing a total of 5000 numeric and graphic data results, color video display monitor, and keyboard. The keyboard allows entry of sample identification number, patient name, sex, date of birth, physician, collection date and time, and comments. In addition, limits and reference ranges can be printed with each patient’s results. Counting of blood cells is based on the volumetric impedance method, directly measuring white blood cells (WBC), red blood cells (RBC), hemoglobin (HGB), platelets, mean corpuscular volume (MCV), and mean platelet volume, and automatically calculating hematocrit (HCT), mean corpuscular hemoglobin (MCH), MCH concentration (MCHC), RBC distribution width, plateletcrit, and platelet distribution width. The instrument differentiates the subpopulations of lymphocytes, granulocytes, and the mid-cell fraction (eosinophils, basophils, monocytes, and precursors of WBCs) by electronic sizing. Specially formulated reagents cause the WBC membrane to shrink around the nucleus while keeping the cell intact, allowing separation of white cells according to their volume. Lymphocytes fall within the small-cell region, neutrophils within the large-cell region, and the remaining cells into the mid-size cell region. The three-part differential screen is provided …
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