Abstract
A clinical evaluation of 300 Mexican women accumulating 5902 treatment cycles representing 454 woman-years with 4 mg norethindrone acetate and .05 mg ethinyl estradiol (Anovlar) is presented. Each woman was instructed to take 1 tablet daily for 20 consecutive days beginning on Cycle Day 5. Anovlar was virtually 100% effective. Unpleasant side effects were minimal and transient occurring principally in the first 3 cycles and disappearing rapidly thereafter. Acceptability was high in women of all social classes. Fertility was rapidly restored after discontinuing medication. Extensive laboratory tests confirm the harmlessness of this compound. Consistent negative Papanicolaou tests during long-term treatment with this compound as with other progestagen-estrogen compounds warrent further study to determine a possible anticarcinogenic effect.(AUTHORS MODIFIED)
Published Version
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