Abstract
Clinical Evaluation of Nitrofurantoin in Patients of Acute Lower Urinary Tract Infection
Highlights
Bansal N, et al Int J Pharm PharmacolUrinary Tract Infection (UTI) is one of the most common bacterial infections and second most common infectious disease in the community practice [1]
The agents most commonly used for the treatment of uncomplicated UTIs include the combination drug trimethoprim and sulfamethoxazole, trimethoprim, β lactams, fluoroquinolones, nitrofurantoin, and fosfomycin tromethamine
Nitrofurantoin has traditionally been prescribed as 7-day regimen, similar microbiological and clinical efficacies are noted with a 5-day course
Summary
Bansal N, et al Int J Pharm PharmacolUrinary Tract Infection (UTI) is one of the most common bacterial infections and second most common infectious disease in the community practice [1]. All the age groups from children to geriatric are affected It is one of the common cause of morbidity in both outpatient as well as hospitalized patients. The agents most commonly used for the treatment of uncomplicated UTIs include the combination drug trimethoprim and sulfamethoxazole, trimethoprim, β lactams, fluoroquinolones, nitrofurantoin, and fosfomycin tromethamine. These agents are preferred because of their safety, spectrum of activity against suspected uropathogens, and favorite pharmacokinetic profiles. Resistance to nitrofurantoin remains low despite >60 years of use Since this drug affects bacterial metabolism in multiple pathways, several mutational steps are required for the development of resistance. Nitrofurantoin has gained importance recently because it has retained activity against a useful proportion of urinary tract coliforms that have acquired resistance to trimethoprim, oral β lactams and quinolones [12]
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