Clinical evaluation of multimodality analgesia for patients undergoing radical resection of colon cancer

Abstract

Objective To explore the efficacy and safety of multimodality analgesia for patients undergoing radical resection of colon cancer.Methods Seventy patients aged 46-75 years old,undergoing the radical resection of colon cancer were divided randomly into two groups:the trial group (parecoxib preemptive analgesia and ropivacaine local analgesia combined with sufentanil patient-controlled intravenous analgesia) and the control group (sufentanil patient-controlled intravenous analgesia only),each group of 35 patients.The visual analogue scale (VAS) and the usage amount of sufentanil were recorded at 12,24,48 h after operation.The number of unsatisfied demand and the number of successfully delivered doses,sufentanil consumption at 12 h and 24 h after operation,the patients' global evaluation of the postoperative analgesia and adverse effects related to analgesia were recorded and compared between the two groups.Results The VAS scores at 12,24 h after operation in trial group were lower than those in control group [(3.1 ± 1.0) scores vs.(4.0 ± 1.3) scores,(2.8 ± 1.4) scores vs.(3.7 ± 1.2) scores].The degree of satisfaction in trial group was higher than that in control group(P ＜ 0.05).The demand and the number of successfully delivered doses and the usage amount of sufentanil in trail group were significantly lower than those in control group (P ＜ 0.05).The incidence of respiratory depression,nausea and vomitting in trial group were significantly lower than those in control group[0 vs.5.7％(2/35),2.9％(1/35) vs.11.4％ (4/35)] (P ＜ 0.05).Conclusion Multimodality analgesia may have the good analgesic effect in the patients undergoing radical resection of colon cancer,and with fewer adverse events. Key words: Colonic neoplasms; Multimodality analgesia; Analgesia efficacy; Radical operation