Abstract

Objective To determine the value of multimodal analgesia used to reduce the degree of postoperative cognitive dysfunction (POCD) in the aged patients undergoing total hip-replacement surgery.Methods Fifty ASA Ⅱ-Ⅲ patients aged 60-79 years old,undergoing total hip-replacement surgery were divided randomly into trial group and control group,each group 25 patients.The visual analogue scale (VAS) and the usage amount of sufentanil were recorded after operation.The mini-mental state examination (MMSE) was used to assess the cognitive function before operation and after operation.Results The VAS scores after operation for 3 d in two groups was significantly lower than that after operation for 1 d (P ＜ 0.05),the VAS scores after operation for 1,2 d in trial group was significantly lower than that in control group (P ＜ 0.05).The usage amount of sufentanil at every time in trial group was also lower than that in control group (P ＜0.05).The MMSE scores before operation and after operation for 3 d in two groups had no significant difference (P ＞ 0.05).The MMSE scores after operation for 1,2 d in trial group was significantly higher than that in control group (P ＜ 0.05).The MMSE scores after operation for 1,2 d in two groups was significantly lower than that before operation (P ＜ 0.05).Severe POCD of both groups was not occurred.Conclusion Multimodal analgesia may reduce early postoperative cognitive dysfunction of the aged patients undergoing total hip-arthroplasty via general anesthesia. Key words: Multimodal analgesia; Postoperative cognitive dysfunction; Minimetal state examination

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