Abstract
This chapter presents a few experimental studies on clinical enzymology in the evaluation of heart and liver disease. It describes the importance of organ specificity in relation to the selection of enzyme tests and the diagnosis of myocardial infarction. In a study described in the chapter, it was observed that bromsulfalein retention and prothrombin time were more sensitive than any of the enzyme tests studied in detecting injury secondary to chronic congestive failure. The chapter also presents a longitudinal study of several serum constituents in a patient with infectious hepatitis. A patient with unexplained alkaline phosphatase activity may present a problem in differential diagnosis. The issue of sensitivity in the detection of increased biliary pressure was earlier investigated by Reichard, who measured enzyme activity in cholecystectomized patients following the ingestion of a fatty meal and the administration of morphine. The data indicated that the serum enzyme activity frequently increased and that OCT was more sensitive than GPT or GOT.
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