Clinical Efficacy of Tacrolimus Ointment + 3% Boric Acid Lotion Joint Chinese Angelica Decoction in Chronic Perianal Eczema.

Weiwei Gao,Jinxin Zhu,Yuegang Wei,Xin Jin,Xueli Qiao,Tao Huang

doi:10.1155/2021/1016108

Abstract

Objective To unearth the clinical efficacy of tacrolimus ointment + 3% boric acid lotion joint Chinese angelica decoction in chronic perianal eczema. Methods Patients with chronic perianal eczema admitted to hospital from June 2018 and June 2019 were retrospectively analyzed. Patients in the control group (n = 38) underwent basic therapy with tacrolimus ointment + 3% boric acid lotion, whereas those in the observation group (n = 38) were given oral Chinese angelica decoction on the basis of the above therapy. Patient's baseline information before therapy and clinical symptoms after therapy were observed and compared, including pruritus ani score, anus drainage and damp score, skin lesion score, skin lesion area score, life quality index score, and IL-2, IL-4, and IgE levels in serum. Overall efficacy in the two groups was also evaluated. Results No significant differences were found in the baseline information between the observation group and control group before therapy. After therapy, pruritus ani score (P = 0.023), anus drainage and damp score (P = 0.041), skin lesion score (P = 0.025), and skin lesion area score (P = 0.035) of patients in the observation group were remarkably lower than those in the control group. Significantly higher release levels of clinical symptoms of patients in the observation group were indicated. With respect to the control group, the life quality score (P = 0.020) and IgE level in serum (P = 0.003) of patients in the observation group were significantly lower, while IL-4 level in serum was significantly higher (P = 0.129). The therapy in the observation group achieved better clinical efficacy. Overall efficacy in the observation group was markedly favorable with respect to the control group. Conclusion With respect to tacrolimus ointment + 3% boric acid lotion, patients with chronic perianal eczema displayed better clinical efficacy after jointly being treated by Chinese angelica decoction.

Highlights

Perianal eczema is a skin disease in perianal skins and mucosae and may spread to perineal region and externalia [1]
Three main types like irritant toxic, atopic, and anaphylactic contact dermatitis may be caused by various colon diseases, skin diseases, anaphylactic diseases, or pathogens [2,3,4]
All patients were diagnosed and systematically treated in hospital during June 2018-June 2019. They were divided into a control group (n = 38) and an observation group (n = 38) according to therapy plans

Summary

Introduction

Perianal eczema is a skin disease in perianal skins and mucosae and may spread to perineal region and externalia [1]. Clinical symptoms of perianal eczema are pruritus, calor, and exudative lesions. Three main types like irritant toxic, atopic, and anaphylactic contact dermatitis may be caused by various colon diseases, skin diseases, anaphylactic diseases, or pathogens [2,3,4]. Glucocorticoid drugs are given to treat perianal eczema patients and can achieve relatively ideal efficacy in the early stage. A massive number of investigations suggested that patients are prone to rely on these drugs, and after withdrawal, they are prone to suffer from disease recurrence and adverse events [5, 6]. A more effective alternative is urgent for disease treatment

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Results

Conclusion