Abstract
Aim: The aim of this study was to evaluate the efficacy of a locally delivered 2% minocycline as an adjunct to scaling and root planing plus oral hygiene measures in treating chronic periodontitis smoker patients. Materials and Methods: This was a randomized controlled trial using a split-mouth study design. Twenty pairs of sites in twenty smoker patients with similar deep probing depths were randomly allocated to test and control groups. The test sites received minocycline after root debridement. The clinical parameters included the plaque index, probing pocket depths, attachment levels, and bleeding upon probing. They were evaluated at the baseline, and after 3 and 6 months. Results: Both the test and control sites showed statistically significant improvements in the clinical periodontal parameters over the baseline measurements during the study period (P<.05). In follow-up, the intervals sites that received minocycline showed more favorable results manifested by probing depth reduction. This improvement was constant at 3 and 6 months and the difference between the two groups was statistically significant (P<.05). Conclusion: The study results show that patient motivation to maintain meticulous oral hygiene self-care with adjunctive professional dental care using local delivery 2% minocycline can significantly enhance treatment outcome of deep periodontal pockets in chronic periodontitis smoker patients.
Highlights
Local delivery of antimicrobial agents in treating periodontitis patients is becoming more prevalent since it leads to higher concentration of the drug at the intended site of action using a lower dose with an associated reduction in side effects relative to systemic administration [1,2]
The study results show that patient motivation to maintain meticulous oral hygiene self-care with adjunctive professional dental care using local delivery 2% minocycline can significantly enhance treatment outcome of deep periodontal pockets in chronic periodontitis smoker patients
This study was conducted at the Department of Oral Surgical Sciences, Division of Periodontology, Faculty of dentistry, Beirut Arab University (BAU)-Lebanon after approval of Institutional Review Board (IRB) with trial NO.2014H-004-DR-0017.Patients were first briefed about the study and written consent was obtained
Summary
Local delivery of antimicrobial agents in treating periodontitis patients is becoming more prevalent since it leads to higher concentration of the drug at the intended site of action using a lower dose with an associated reduction in side effects relative to systemic administration [1,2]. Despite many studies in the periodontal literature on the local delivery concepts, surprisingly there are few studies that demonstrate the clinical efficacy using intra-pocket delivery systems [3,4,5]. Several studies have failed to show clinically important effects provided by the intra-pocket drug delivery systems when used as individual mono-therapy. Studies have shown that smoking increases the risk for developing periodontal disease by two to five folds, and these effects seem to be dose dependent. Smoking accelerates the progression of periodontitis and jeopardizes the healing
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