Clinical efficacy of Deanxit in non-erosive gastroesophageal reflux disease with anxiety and depression

Abstract

Objective To investigate clinical effects of Deanxit in non-erosive gastroesophageal reflux disease (NERD) with anxiety and depression. Methods A total of 76 patients diagnosed NERD with anxiety and depression by endoscopy and hospital anxiety and depression scale (HAD) were randomly divided into regular treatment group and Deanxit treatment group. Clinical efficacy, symptom score, and anxiety and depression score were observed after one week, four weeks, and eight weeks. Results Deanxit significantly increased the clinical efficacy after one week (P<0.01) and remission rate after one week (P<0.05), four and eight weeks (P<0.01). It improved symptoms, depression, and anxiety, which showed significant differences (P<0.01) compared to control group after one week, four and eight weeks administration. Conclusions Deanxit can be applied in NERD with anxiety and depression treatment, which has quick effect and high remission rate, and improve patient's reflux symptoms and anxiety depression. Key words: Flupenthixol/TU; Gastroesophageal reflux/CO/DT; Anxiety; Depression