Abstract
Objectives: The purpose of this systematic review was to evaluate the effects of herbal medicine on Chemo -Radiotherapy-induced oral mucositis.Methods: Electronic databases were used to search for studies published through 10 years until October 2022, and a randomized controlled study was conducted to evaluate efficacy of herbal medicine on chemo-radiotherapy-induced oral mucositis. Study quality was assessed using the Cochran’s risk bias tool.Results: Two-hundred and three articles were initially searched, and 11 studies (head and neck cancer, breast cancer, colorectal cancer, esophageal cancer etc. undergoing radio-chemotherapy were included in analysis. The effect of herbal medicine on chemo-radiotherapy-induced oral mucositis, 9 studies reported that herbal medicine was more effective than the placebo group or conventional treatment. One study reported that the effect of the herbal compound treatment group was similar to that of the conventional herbal medicine, and one study reported that there was no difference in effect between the two herbal medicines and the group without treatment.Conclusion: This study suggests that herbal medicine effectively relieves the symptoms of chemo-radiotherapy -induced oral mucositis. However, there is limited evidence that herbal medicine may relief chemo-radiotherapy -induced oral mucositis, so further investigation is needed.
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