Abstract
Objective To evaluate the efficacy of alteplase combined with enoxaparin sodium in the treatment of ST-elevation myocardial infarction (STEMI). Methods A total of 156 STEMI patients treated in the department of cardiology from Feb.2016 to Jan.2018 were selected as the study subjects. According to the random number table method, the patients were randomly assigned to the treatment group and the control group, 78 cases in each group. The treatment group received intravenous thrombolysis with alteplase and enoxaparin sodium. The control group used urokinase combined with enoxaparin sodium for intravenous thrombolytic therapy. The total treatment efficiency of the two groups were compared. The vascular recanalization and adverse reactions of the patients at 30 minutes, 60 min, 90 min, and 120 min after thrombolytic treatment were compared. Results Compared with the control group, the total effective rate in the treatment group was significantly increased [91.0% (71/78) vs. 73.0% (57/78), χ2=8.969, P=0.011]. At the time of 60 min, 90 min and 120 min after thrombolysis, the vascular recanalization rate of the treatment group was significantly higher than that of the control group (all P>0.05). After treatment, compared with the control group, the ST segment shift, Q wave/R wave and Q wave time of the treatment group were significantly reduced (all P<0.05). Compared with the control group, the incidence of pericardial effusion, postinfarction cramps, death, ventricular aneurysm, heart failure/cardiogenic shock, and severe arrhythmia was significantly lower in the treatment group (P<0.05). Conclusions Alteplase combined with enoxaparin sodium has a higher revascularization rate and clinical efficacy in the patients with STEMI, and has fewer adverse reactions and high safety, so it is worthy of clinical application. Key words: Alteplase; Thrombolysis; ST-elevation myocardial infarction; Efficacy
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