Abstract
Background:Chronic heart failure (CHF) is one of the most serious cardiovascular diseases. Shenqi Fuzheng injection (SQFZI), as a Chinese herbal injection, is usually used for the treatment of CHF. However, the clinical evidence of SQFZI for the treatment of CHF is unclear.Methods:Two researchers will dependently search literatures of SQFZI for CHF from Chinese National Knowledge Infrastructure database, VIP database, Chinese Biological and Medicine database, Wangfang database, MEDLINE, EMBASE, Cochrane Library and Web of Science. These inclusive data of included studies will be conducted by RevMan 5.3 software.Results:This meta-analysis and systematic review will provide a series of outcome measures to verify clinical efficacy and safety of SQFZI for treating CHF, including New York Heart Association (NYHA) function classification, left ventricular ejection fraction, left ventricular end-diastolic dimension, cardiac output, stroke volume, brain natriuretic peptide, N-terminal pro-brain natriuretic peptide, and adverse events.Conclusions:This meta-analysis and systematic review will provide up-to-date clinical evidence to assess SQFZI treatment efficacy for CHF patients.
Highlights
Chronic heart failure (CHF) is a heart disease which is caused by myocardial damage, heart overload and systolic dysfunction.[1]
CHF is a progressive disease, even if no new myocardial damage is produced from the onset.[3]
Myocardial injury is the main pathogenesis of CHF, which can lead to the complex clinical syndrome of low ventricular pumping and filling function.[13]
Summary
Chronic heart failure (CHF) is a heart disease which is caused by myocardial damage, heart overload and systolic dysfunction.[1]The high incidence and mortality of CHF have brought enormous burden and challenge to social economy and medical resources.[2]CHF is a progressive disease, even if no new myocardial damage is produced from the onset.[3]. Chronic heart failure (CHF) is a heart disease which is caused by myocardial damage, heart overload and systolic dysfunction.[1]. The high incidence and mortality of CHF have brought enormous burden and challenge to social economy and medical resources.[2]. CHF is a progressive disease, even if no new myocardial damage is produced from the onset.[3] Patients show no obvious clinical signs and symptoms, but this does not mean the disease will not further develop. Chronic heart failure (CHF) is one of the most serious cardiovascular diseases. Shenqi Fuzheng injection (SQFZI), as a Chinese herbal injection, is usually used for the treatment of CHF. The clinical evidence of SQFZI for the treatment of CHF is unclear
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