Clinical efficacy and safety of Qingyi Decoction administered by nasojejunal tube for the treatment of severe acute pancreatitis

Abstract

Objective To compare the clinical efficacy and safety of Qingyi Decoction (a preparation of Chinese herbal medicine) between two different routes of the administration by using nasogastric tube or nasojejunal tube for treatment of severe acute pancreatitis (SAP). Methods A total of 79 SAP patients enrolled were randomly divided into nasogastric tube group (n=41) and nasojejunal tube group (n=38) according to the random number table method. In addition to the conventional therapy, they were treated with Qingyi Decoction administered by using nasogastric tube or nasojejunal tube. Results After treatment for 14 days, the levels of C-reactive protein (CRP), procalcitonin (PCT) and white blood cell count (WBC), urinary bladder pressure, and APACHE Ⅱ score in nasojejunal tube group were significantly lower than those in nasogastric tube group (P<0.05). The time required for the recovery of bowel sounds, length of abnormal serum amylase persistence, the duration of abdominal pain, the time necessary for mechanical respiratory support in nasojejunal tube group was significantly shorter than those in nasogastric tube group. The blood fungus infection rate and pulmonary fungus infection rate in nasojejunal tube group were significantly lower than those in nasogastric tube group, and 28-day survival rate in nasojejunal tube group was significantly higher than that in nasogastric tube group (P<0.05). Conclusion The nasojejunal tube route for the administration of Qingyi Decoction for the treatment of SAP can effectively alleviate the severity of patient’s condition, shorten the time required for improving clinical symptoms, reduce the incidence of morbidity and mortality, and it is worthy of further popularization in clinical practice. Key words: Severe acute pancreatitis; Nasojejunal tube; Nasogastric tube; Qingyi Decoction; Clinical curative effect