Abstract
Objective:To study the clinical effect of ganglioside (GM) and fructose-1, 6-diphosphate (FDP) on neonatal heart and brain injuries after asphyxia.Methods:Ninety-one neonates with asphyxia neonatal heart and brain injuries were randomly divided into an observation group and a control group. Both groups were given symptomatic treatment as soon as possible. On this basis, the observation group was given 200 mL of 5% glucose injection and 20 mg of GM and 250 mg/kg·d FDP by intravenous infusion. The above two drugs were given once a day for 14 days. The control group was given 20 mL of 5% glucose injection, 2 mL of cerebrolysin and 250 mg/kg·d FDP by intravenous infusion, once a day for 14 days. Both groups were administered on the first day after admission, and the course of treatment was 14 days. The treatment outcomes of the two groups were compared by detecting the levels of glycogen phosphorylase isoenzyme BB (GPBB), cTn-I and CK-MB, MRI results and Neonatal Behavioral Neurological Assessment (NBNA) scores before and after treatment.Results:The levels of GPBB, cTn-I and CK-MB in the observation group were significantly higher than those of normal neonates. After treatment, the levels of cTn-I and CK-MB in the observation group were closer to those of normal neonates compared with the control group, with significant differences (P<0.05). There was a significant difference in the brain MRI examination between the two groups (P<0.05). The NBNA scores of the two groups were significantly different before and after treatment (P<0.05). The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).Conclusion:Neonatal heart and brain injuries after asphyxia can be well treated by combining GM with FDP.
Highlights
Neonatal asphyxia, as one of the leading causes of neonatal death, is induced by hypoxemia, hypercapnia and metabolic acidosis for no spontaneous breathing or respiratory depression within one minute after delivery.[1]
The levels of cTn-I and CK-MB in the observation group were closer to those of normal neonates compared with the control group, with significant differences (P
The results showed that the levels of glycogen phosphorylase isoenzyme BB (GPBB), cTn-I and CK-MB were the highest in the severe asphyxia group, and the values of the mild asphyxia group were lower compared with the former group, but the values of both groups were higher than those of normal neonates
Summary
As one of the leading causes of neonatal death, is induced by hypoxemia, hypercapnia and metabolic acidosis for no spontaneous breathing or respiratory depression within one minute after delivery.[1] Ischemia and hypoxia are the pathological basis and main manifestations after asphyxia, while the heart and brain are the important organs most vulnerable to damage.[2] According to many years of experience in the treatment of neonatal asphyxia, we detected the levels of glycogen phosphorylase isoenzyme BB (GPBB), cTn-I and CK-MB that play important. Pak J Med Sci September - October 2017 Vol 33 No 5 www.pjms.com.pk 1199 roles in heart and brain injuries. MRI was used to appropriately evaluate the degree of injury after asphyxia and to provide laboratory basis, so as to explore the clinical effect and feasibility of combining ganglioside (GM) with fructose 1, 6-diphosphate (FDP)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
