Application value of amplitude integrated electroencephalography (aEEG) combined with neonatal behavioral neurological assessment (NBNA) in brain injury of premature infants

Abstract

Objective To evaluate the effect and value expression of amplitude integrated electroencephalography (aEEG) combined with neonatal behavioral neurological assessment (NBNA) in the diagnosis of brain injury of premature infants (BIPI). Methods From January 2017 to December 2018, 218 cases of premature infants (gestational age was 28 to 36 weeks) in our hospital were divided into brain injury group (102 cases) and non brain injury group (116 cases) according to the presence of brain damage factors. Within 6 hours after premature birth, aEEG was recorded in continuous 3 hours; head B ultrasonic examination was performed within 24 hours and on the third day after birth; head Magnetic Resonance Imaging (MRI) detection was performed before leaving the hospital. In addition, NBNA score was performed until 40 weeks of gestational age. According to the characteristics of aEEG and NBNA score, the value of combined two methods in the diagnosis of brain injury in premature infants was evaluated. Results Clinical application showed that the sensitivity of aEEG combined with NBNA in the diagnosis of brain injury of premature infants was 91.87%, which was higher than 86.31% of aEEG and 76.32% of NBNA; the specificity of aEEG combined with NBNA was 67.53%, which was lower than 75.42% of aEEG and 86.37% of NBNA; the area under the ROC curve of combined diagnosis was 0.856, which was higher than 0.813 of aEEG and 0.754 of NBNA. Conclusion The combined evaluation method has a larger area under the ROC curve and higher sensitivity than single evaluation method, is worthy of clinical promotion and application. Key words: Amplitude integrated electroencephalography; Neonatal Behavioral Neurological Assessment; Premature infant; Brain injury