Clinical effect of MR-guided high intensity focused ultrasound and gonadotropin releasing hormone agonist combined with levonorgestrel-releasing intrauterine system in the treatment of recurrent uterine fibroids

Abstract

Objective To explore the clinical effects of magnetic resonance guided high intensity focused ultrasound(MRgHIFU) and gonadotropin releasing hormone agonist(GnRH-a) combined with levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of recurrent uterine fibroids. Methods Eighty patients of recurrent uterine fibroids from April 2015 to June2017 in the First Hospital of Harbin were collected and randomly divided into the observation group and control group.MRgHIFU was used in the observation group were employed, and patients in the control group were treated with ING-IUS after first injecting GnRH-a.The tumor volume, hemoglobin level, menstrual quantity and adverse reactions were compared before and at 3 months, 6 months after treatment. Results After 6 months, the size of the uterine myoma in the observation group was ((80.23±4.35) cm3), significantly lower than that of the control group ((135.46±9.25) cm3), and the difference was statistically significant (t=6.01, P<0.05). At 3 and 6 months after treatment, the amount of menstruation in the observation group was significantly lower than that of the control group( (66.37±12.12)points vs.(40.46±10.15) points; (98.42±14.12) points vs.(68.26±11.38) points). The difference was statistically significant (t at 3 months after treatment=4.52, P<0.05, t at 6 months after treatment=3.53, P<0.05). After 6 months of treatment, the hemoglobin value of the observation group was significantly higher than that of the control group ((142.12±4.24) g/L vs.(108.27±3.09) g/L), the difference was statistically significant (t=5.02, P<0.05), while the adverse reactions such as vaginal bleeding, hot flashes and night sweats were lower than those of the control group (2.5% (1/40) vs.7.5% (3/40)) (χ2=3.99, P<0.05). Conclusion Magnetic resonance guided high intensity focused ultrasound was considered as safe and effective in treating uterine fibroids, which is a new and noninvasive therapeutic methed, Key words: Magnetic resonance guided high intensity focused ultrasound; Gonadotropin releasing hormone agonist; Levonorgestrel-releasing intrauterine system; Recurrent uterine fibroids