Clinical effect of continuous renal replacement therapy in the treatment of sepsis

Abstract

Objective To study and discuss the clinical effect of continuous renal replacement therapy (CRRT) in the treatment of patients with sepsis in intensive care unit (ICU). Methods From January 2014 to February 2017, 100 patients with sepsis in the ICU of Yuncheng Central Hospital were selected and randomly divided into control group and observation group, with 50 cases in each group.The control group was treated with hemoperfusion treatment, the observation group was treated with CRRT.The blood coagulation function, clinical efficacy, renal function, inflammatory factors index were compared between the two groups. Results The total effective rate of the observation group was 96%, which was significantly higher than 80% of the control group (χ2=6.061, P<0.05). After treatment, the blood creatinine, urea nitrogen in the observation group were (94.09 ±20.69)μmol/L, (8.94±2.87)mmol/L, respectively, which were lower than those in the control group [(119.43±26.57)μmol/L, (12.37±3.70)mmol/L] (t=5.321, 5.180, all P<0.05). The APTT, PT of the observation group were (19.10±2.14)s, (8.24±0.97)s, respectively, which were shorter than those of the control group [(21.84±2.75)s, (9.32±1.15)s] (t=5.560, 5.076, all P<0.05). The levels of CRP, IL-6 of the observation group were (8.32±1.89)mg/L, (109.53±36.29)ng/L, respectively, which were lower than those of the control group [(12.65±3.47)mg/L, (148.36±43.64)ng/L] (t=7.749, 4.838, all P<0.05). Conclusion CRRT treatment for the sepsis patients during ICU monitoring can effectively improve the clinical curative effect, improve renal function, reduce the damage of blood coagulation function, inhibit the inflammatory reaction in the body, and is beneficial for the prognosis. Key words: Sepsis; ICU; Continuous renal replacement therapy; Kidney function tests; Blood coaguation factors; Chemokines