Clinical effect of cetylpyridinium chloride buccal tablets on oral candidosis

Abstract

Objective This study is aimed to investigate the effect of treatment of oral candidosis with cetylpyridinium chloride buccal tablets and cetylpyridinium chloride buccal tablets combined sodium bicarbonate. Methods Patients with erythema or pseudomonas oral candidosis were randomly divided into experimental group 1 (cetylpyridinium chloride buccal tablets) , experimental group 2 (cetylpyridinium chloride buccal tablets combined 2.5% sodium bicarbonate) and control group (2.5% sodium bicarbonate) . Improvement rate of each symptom including dry, pain, erythema or pseudomembrane and candida clearance rate were analysed among three groups. SPSS 20.0 statistical software was used to conduct matching sample t test, paired sample rank and test of measurement data. We used Chi-square test for counting data and the significance level was 0.05. Results The 73 cases were randomly divided into three groups and each group contained 25, 24 and 24 cases. The three groups all can show improved symptoms of oral candidosis and reduced number of fungal. The total effective efficiency of the three groups on the improvement of dry was 85%, 80% and 84.2% respectively with no statistically significant (P= 0.711) difference between the three groups. The total effective rate of pain improvement in the three groups was 90.9%, 95.2% and 95.2% respectively and there was no statistically significant difference between the three groups (P= 0.880) . The total effective rate of improvement of erythema or pseudomonas was 88%, 95.8% and 50% respectively. There was no statistically significant difference between the experimental group 1 and the experimental group 2 (P= 0.546) and such effect on both of the two groups were better than the control group (χ21 group= 10.091, P1 group= 0.001; χ22 group= 13.819, P2 group<0.001) . The total rate of removal effect of the fungus in the three groups was 80%, 91.7%, 79.2% respectively. The effect of experimental group 2 was better than that of the experiment group 1 and the control group (χ21 group= 6.026, P1 group= 0.014; χ2control group= 5.147, Pcontrol group= 0.023) . There was no statistical difference between the experimental group 1 and the control group on removal effect of the fungus (P= 0.992) . Conclusions Cetylpyridinium chloride buccal tablets can treat erythema/pseudomonas oral candidiasis. The antifungal effect of cetylpyridinium chloride buccal tablets combined sodium bicarbonate on oral candidiasis was more superior. Key words: Candidiasis, oral; Cetylpyridinium chloride buccal tablets; Sodium bicarbonate, mouthwashes