Abstract
Objective To study the clinical effects of torasemide in the treatment of nephrotic syndrome with intractable edema (referred to the infant nephropathy).Methods Clinical analysis was carried out to infants with kidney disease admitted in our department from January 2010 to December 2013,32 cases of infant kidney disease were divided into Torasemide group and Furosemide group,on the basis of the two oral prednisone sufficient quantities [2 mg/(kg · d) or 60 mg/(m2 · d)].Torasemide group,16 patients,were given intravenous infusion of torasemide 1-2 mg/(kg · d),Furosemide group with 16 cases were given intravenous infusion of furosemide 1-2 mg/(kg · d) for 5 days.The patients of two groups were detected for 24 h urine,electrolyte changes,and we recorded the adverse reactions before and after treatment of 2,4,6 days.Changes in the amount of urine,serum potassium and trioxypurine as the primary efficacy endpoint.Results Among the children of two groups with clinical use of torasemide and furosemide,urine output increased significantly as compared with that before treatment,showing edema fading,weight lose.Total efficiency in two groups was statistically significantly different (94％ vs 81％).Serum potassium concentration in Furosemide group was significantly lower than that of Torasemide group (P ＜ 0.05),trioxypurine concentration in Furosemide group was significantly higher than that of Torasemide group (P ＜ 0.05).Conclusion The torasemide in the treatment of nephrotic syndrome with intractable edema has significant clinical curative effect,with less side-effect,without obvious effect to electrolyte and renal function,which is worthy of clinical promotion. Key words: Nephrotic syndrome; Edema; Torasemide; Furosemide; Curative effect
Published Version
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