Clinical curative effect observation of Bixie Qufeng Decoction combined with western medicine in the treatment of acute gouty arthritis and its influence on inflammatory factors

Abstract

Objective To explore the clinical curative effect observation of Bixie Qufeng Decoction combined with western medicine in the treatment of acute gouty arthritis and its influence on inflammatory factors. Methods Ninety patients with acute gouty arthritis in Taizhou Traditional Chinese Medicine Hospital from April 2018 to April 2019 were enrolled. According to the random table method, they were divided into two groups, with 45 patients in the control group and 45 patients in the observation group. The control group was treated with loxoprofen sodium tablets, while the observation group was treated combined with Bixie Qufeng Decoction on the basis of oral administration. Both groups were treated for 2 weeks. The therapeutic effects of the two groups were compared. The changes of joint tenderness, joint swelling score, erythrocyte sedimentation rate, serum uric acid and inflammatory factors before and after treatment were compared. Results The total effective rate of the observation group was higher than that of the control group [93.33%(42/45) vs. 71.11%(32/45)], and there was significant difference (P<0.05). After treatment, the scores of joint tenderness and joint swelling in two groups decreased significantly (P<0.05), and the scores of joint tenderness and joint swelling in the observation group were lower than those in the control group [(0.42 ± 0.13) scores vs. (0.97 ± 0.26) scores, (0.35 ± 0.09) scores vs. (0.85 ± 0.14) scores] (P<0.05). After treatment, the levels of erythrocyte sedimentation rate (ESR) and uric acid in the two groups decreased significantly (P<0.05), and the levels of ESR and uric acid in the observation group were lower than those in the control group [(10.83 ± 2.46) mm/1 h vs.(17.69 ± 5.14) mm/1 h, (341.24 ± 17.89) μmol/L vs. (423.16 ± 14.36) μmol/L] (P<0.05). After treatment, the levels of C-reactive protein (CRP), interleukin (IL)-1β and IL-6 in serum of the two groups decreased significantly (P<0.05), and the levels of CRP, IL-1β and IL-6 in serum of the observation group were lower than those of the control group [(6.14 ± 1.27) mg/L vs. (11.32 ± 3.12) mg/L, (3.28 ± 0.49) ng/L vs. (5.48 ± 0.91) ng/L, (5.47 ± 2.19) n/L vs.(9.98±1.65) ng/L](P<0.05). Conclusions The combination of Bixie Qufeng Decoction and western medicine has obvious clinical effect on acute gouty arthritis patients, and can reduce inflammation, which is worthy of clinical reference. Key words: Arthritis, gouty; Drugs, Chinese herbal; Bixie Qufeng Decoction; Comparative study; Inflammatory factors