Abstract
Objective To investigate the clinical characteristics of tracheobronchopathia osteochondroplastica (TO). Methods The clinical data of six patients with TO from November 2016 to November 2018 were retrospectively analyzed. The etiology, clinical manifestations, diagnosis, and treatment of TO were summarized. Result All six patients with TO were middle-aged males, confirmed by histopathological examination. The main clinical symptoms were cough, sputum, hemoptysis, chest pain, and repeated pulmonary infection. Some patients could make a preliminary diagnosis by chest CT, and bronchoscopy showed that TO mainly occurred in the trachea and the main bronchus and was more likely to invade the right bronchus. The treatment mainly includes anti-infection, phlegm-resolving, and other symptomatic treatment. Conclusion TO is a benign disease predisposing to adults, and males are more likely to be affected. Its clinical manifestations are lack of specificity, and the cause may be related to chronic infection. Bronchoscopy combined with histopathological examination is the primary approach for the diagnosis of TO. There is no well-recognized treatment standard for TO, and the judgment of therapeutic effect is inconsistent. It is necessary to improve the understanding of this disease from a clinical perspective.
Highlights
Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease
It was reported that there was no significant difference in the prevalence rate between men and women [7], while others reported that the prevalence rate was about 3 : 1 for men and women [8]. e pathogenesis of TO is unknown, which may be related to congenital tracheobronchial dysplasia, long-term physical, chemical, or mechanical stimulation, chronic inflammation, and metabolic disorders [6]. e most common clinical symptoms of TO include chronic cough and wheezing, and other nonspecific symptoms include chest tightness, shortness of breath, dyspnea, and hoarseness [9]
Chronic infection such as tuberculosis and chronic sinusitis may be involved in the pathogenesis of TO; Helicobacter pylori infection may be related to the pathogenesis of TO, and further study is needed; bronchoscopy
Summary
To investigate the clinical characteristics of tracheobronchopathia osteochondroplastica (TO). E clinical data of six patients with TO from November 2016 to November 2018 were retrospectively analyzed. E etiology, clinical manifestations, diagnosis, and treatment of TO were summarized. All six patients with TO were middle-aged males, confirmed by histopathological examination. E main clinical symptoms were cough, sputum, hemoptysis, chest pain, and repeated pulmonary infection. Some patients could make a preliminary diagnosis by chest CT, and bronchoscopy showed that TO mainly occurred in the trachea and the main bronchus and was more likely to invade the right bronchus. TO is a benign disease predisposing to adults, and males are more likely to be affected. Its clinical manifestations are lack of specificity, and the cause may be related to chronic infection. Bronchoscopy combined with histopathological examination is the primary approach for the diagnosis of TO. It is necessary to improve the understanding of this disease from a clinical perspective
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