Clinical characteristics and risk factors of myocardial injury in patients with sepsis

Abstract

Objective To analyze the clinical characteristics and risk factors of myocardial injury (MI) in patients with sepsis. Methods Totally 160 patients with sepsis in April 2016 to December 2017, divided into the MI group and non-MI group.The clinical data laboratory findings and ultrasonic cardiographic findings were recorded and compared between the two groups. Binary logistic regression analysis was performed to find the independent risk factors of MI in patients with sepsis. Results Total of 160 patients with sepsis 75 (46.9%) patients developed MI.The MI group had older age and more patients with history of hypertension than the non-MI group (P<0.05). In patients with sepsis, diastolic dysfunction accounted for 84.1%, systolic dysfunction accounted for 4.3%, and ventricular wall dyskinesia accounted for 17.3%. Compared with the non-MI group, the MI group had more abnormal wall motion (9.6% vs 25.8%, P=0.012), lower interventricular septal amplitude (0.87±0.16 vs 0.80±0.21, P=0.03) and left ventricular posterior wall amplitude (1.03±0.21 vs 0.96±0.18, P=0.034), and decreased fractional shortening (P=0.033). Binary logistic regression analysis showed that age (RR=1.033, P=0.018) and decreased fractional shortening (RR=0.000, P=0.024) were independent risk factors of MI in patients with sepsis. Conclusions Age and decreased fractional shortening were independent risk factors of myocardial injury in patients with sepsis. Key words: Sepsis; Myocardial injury; Fractional shortening