Abstract
Objective To summarize the clinical characteristics of neonatal gastric perforation and analyze its relationship with the prognosis of neonatal gastric perforation, so as to provide basis for improving clinical therapeutic effect. Methods The clinical data of 62 neonates with gastric perforation admitted to Department of Pediatric General Surgery of the Third Affiliated Hospital of Zhengzhou University from December 2012 to November 2018 were analyzed retrospectively. The gender, gestational age, birth weight, perforation type, operation time and application of non-invasive congtinuous positive airway pressure (nCPAP) before onset were counted for analysis on relationship between clinical characteristics and prognosis of children with gastric perforation. Results Of the 62 cases, 47 cases were discharged successfully after the operation, 15 cases died with the fatality rate of 24.2%. The pathological findings of 42 cases (67.7%) showed defect of gastric wall muscle layer after operation. There was a significant difference in the timing of surgery between the children with hospital onset and those who were transferred from other hospital after the diagnosis (P<0.05). The time from diagnosis to operation was longer in children who were transferred from other hospital after the diagnosis than hospitalized children. There was no significant difference in the fatality rate of gastric perforation neonates with different genders, gestational ages, birth weight, types of perforation and the history of nCPAP application before onset (P<0.05). However, there was a significant difference in fatality rate among children with different operation time (P<0.05). Conclusions The incidence of gastric perforation in neonates is higher in males than females, which mostly occurred in premature infants (62.9%) and low birth weight infants (69.4%). The perforation type is mainly long hiatal perforation (82.3%). Nearly half of the children have a history of nCPAP before onset. The disease is critical, which progresses rapidly and has a high fatality rate. Early operation and reasonable postoperative treatment are the key to remission. Key words: Neonatal gastric perforation; Premature infant; Low birth weight infant; Operation time; Prognosis
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