Abstract
BackgroundCongenital isolated adrenocorticotrophic hormone (ACTH) deficiency may be rare, but it could be an underestimated cause of neonatal death. Our objective was to shorten the time between first symptoms and diagnosis.MethodsThis single-centre retrospective case-cohort study was carried out on eight consecutive patients.ResultsTwo had the neonatal form and 6 the late onset form. Six were admitted to an intensive care unit at least once for seizures with hypoglycemia, major hypothermia, fever, and/or collapsus. The 2 neonatal cases presented with hypoglycemia and in a state of “apparent death” at birth or hypothermia (29°C) at 6 days. All 6 late onset cases had also been admitted to an emergency department 1–3 times, but had left hospital incorrectly diagnosed. Their first symptoms were noted at 3–12.3 years, and they were diagnosed at 3.3–14.4 years. All had hypoglycemia, and 4 had had seizures. The presenting symptoms were vomiting and/or abdominal pain, asthenia, irritability, difficulty with physical activities, and anorexia. The school performance of 4 deteriorated. Two underwent psychotherapy and treatment for depression, which was stopped when Hydrocortisone® replacement therapy began.The plasma concentrations in spontaneous hypoglycemia were: ACTH<5 to 17.1 pg/mL, with concomitant cortisol <3.5 to 37 ng/mL. The plasma dehydroepiandrosterone sulfate (DHAS) concentrations were low in the 7 evaluated. The coding sequence of TPIT was normal in all.ConclusionSeveral unexplained symptoms in a child, mainly gastro-intestinal symptoms and seizures due to hypoglycemia, may indicate ACTH deficiency. A low or normal basal plasma ACTH despite concomitant low cortisol at 8 a.m. and/or in spontaneous hypoglycemia, associated with low DHAS, in a patient not given corticosteroids is highly suggestive of ACTH deficiency. The isolated character of ACTH deficiency must be confirmed by determining the other hypothalamic-pituitary functions, and Hydrocortisone® replacement therapy initiated in emergency.
Highlights
Congenital isolated adrenocorticotrophic hormone (ACTH) deficiency is a rare condition that was first reported in 1954 [1]
Diagnosis was based on low plasma basal concentrations of ACTH in spontaneous hypoglycemia and/or at 8 a.m. despite concomitant low cortisol
The ages and causes of previous admissions to emergency departments were obtained from the parents and the children’s health records, as were the statural growth curves, the weight changes during the year preceding the diagnosis of ACTH deficiency, and the school performances
Summary
Congenital isolated adrenocorticotrophic hormone (ACTH) deficiency is a rare condition that was first reported in 1954 [1]. But it is considered to be an underestimated cause of neonatal death [2]. The patients may have no symptoms of the disease until decompensation occurs, which may be fatal. There are two forms of isolated ACTH deficiency in childhood. 42 cases of children with isolated ACTH deficiency have been reported. Vallette-Kasic et al [2] reported 27 neonatal cases having ten different mutations in the TBX19 (TPIT gene) in 17 patients. Congenital isolated adrenocorticotrophic hormone (ACTH) deficiency may be rare, but it could be an underestimated cause of neonatal death. Our objective was to shorten the time between first symptoms and diagnosis
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