Clinical assessment of drug adjunctive therapy effects in association with chronic generalized periodontitis and osteoporotic disease

Irina-Georgeta Ursarescu,Liliana Pasarin,Sorina Solomon,Alexandra Martu,Silvia Martu

doi:10.1515/bjdm-2015-0053

Abstract

Aim: The present study proposes an assessment of the clinical effects on periodontal level generated by the adjunctive periodontal therapy with sub-antimicrobial doses of doxycycline in patients with chronic periodontitis and osteoporosis. Materials and Methods: The study group comprised 26 patients with chronic periodontitis and osteoporosis, divided in the study group (classical periodontal debridement and sub-antimicrobial doses of doxycycline for 3 months) and the control group (classical debridement only). We analyzed the periodontal parameters (probing depth, clinical attachment level, PBI and PI indices) at baseline, in the last day of medication and at 3 months after the drug therapy. Results and Discussion: The reduction of the moderate and profound pockets was higher for the group with drug adjunctive therapy. The sites with an initial depth of 0-3mm in the study group presented also a slight attachment gain. Conclusions: The therapy with sub-antimicrobial doses of doxycycline generated significant clinical improvement in patients with chronic periodontitis and osteoporosis, an improvement which can reduce the necessity of surgical procedures.

Highlights

Periodontal treatment was mainly focused along time on reducing the bacterial loading and disorganizing the biofilm by mechanical methods
The present study aims to analyze changes in clinical periodontal parameters that can be expressed as a consequence of host response modulation therapy with sub-antimicrobial doses of doxycycline in patients with periodontal disease and osteoporosis
In order to avoid any risk of biased results, smokers, patients with systemic infectious/inflammatory diseases, allergic patients or patients under therapy with bisphosphonates, patients with periodontal or antibiotic therapy in the last 3 months were excluded from the study

Summary

Introduction

Periodontal treatment was mainly focused along time on reducing the bacterial loading and disorganizing the biofilm by mechanical methods. Recent research led to a shift in the concept of the evolution of periodontal disease. The modulation therapy can be associated to classical therapy of periodontal disease, with the main purpose of reducing the bacterial and inflammatory loading. The only approved systemic therapy of host response modulation in the periodontal disease is the therapy with sub-antimicrobial doses of doxycycline (Periostat®), which inhibit the MMP activity.

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Discussion

Conclusion