Clinical assessment of 0.1% Diclofenac Sodium eye drops on the treatment of acute allergic conjunctivitis

Abstract

Objective To evaluate the clinical values of 0.1% Diclofenac Sodium eye drops,one of non-steroidal anti-inflammatory drugs (NSAIDs),on the treatment of acute allergic conjunctivitis.Methods Ninety patients (180 eyes) with acute allergic conjunctivitis,including seasonal allergic conjunctivitis and perennial allergic conjunctivitis,were enrolled in the study.A randomized and controlled study was adopted 0.05% Emedastine Difumarate eye drops for the group A (first control group),0.1% Pranoprofen eye drops plus 0.05% Emedastine Difumarate eye drops for the group B (second control group) and 0.1% Diclofenac Sodium eye drops plus 0.05% Emedastine Difumarate eye drops for the group C (test group),three times a day for each.The symptoms and signs were evaluated before and after the treatment at 1st day,4th day,7th day and 14th day,respectively,and the side effects were observed.Results There was no significant difference between the group A,B and C in the general state,mean scores of symptoms and signs before the treatment.After the administration,the efficacy rates in the group A,B and C were 6.7%,56.7% and 60.0% at 1st day,20.0%,100.0% and 96.7% at 4th day,53.3%,100.0% and 100.0% at 7th day,and 73.7%,100.0% and 100.0% at 14th day respectively.By further analysis,there was significant difference between the group A and B in the efficacy rates and the cure rates after the administration,as well as the group A and C (all P=0.000),meanwhile,there was no statistical significance between the group B and C (P=0.918,0.147,0.058 and 0.0405 ＞0.05).Furthermore,there was no obvious discomfortableness and adverse reaction observed in the three test group.Conclusions NSAIDs can rapidly and effectively assist to relieve the symptoms and signs of acute allergic conjunctivitis.0.1% Dielofenae Sodium eye drops,which is similar with the imported NSAIDs eye drops in the efficacy and cure rates,have an efficacy and safety to control the inflammation of allergic conjunctivitis. Key words: NSAIDs; Diclofenac Sodium eye drops; Allergic conjunctivitis; Treatment