Clinical applications of vancomycin and norvancomycin in hospitalized neurosurgical patients

Abstract

The medical records of 108 inpatients treated with vancomycin and norvancomycinin were collected and analyzed retrospectively. And 78.7% of all cases were used for therapy and 21.3% for prevention. The pathologic examination submission rate was 88.9% (n=96). The drug utilization index (DUI) of norvancomycin was 0.95 and vancomycin 0.92. The proportion of combination use was 86.1% and a maximum of 3 antibiotics were used. There were 6.5% cases of doubtful adverse drug reaction.The inpatient uses of vancomycin and norvancomycin are basically rational. Indications should be mastered strictly. Empirical and prophylactic uses should be minimized to prevent and delay drug resistance strain from spreading and prolong effectiveness. Necessary therapeutic drug monitoring is required. Key words: Vancomycin; Norvancomycin; Rational drug use