Abstract
PurposeTo evaluate the clinical effects of concentrated growth factors (CGFs) combined with bone substitutes for alveolar ridge preservation (ARP) in the maxillary molar area.MethodsThirty-six patients who underwent extraction of the upper molars were recruited and randomly divided into three groups: 1. Grafted with CGFs combined with deproteinized bovine bone mineral (DBBM) and covered with CGFs membrane (CGFs/DBBM group), 2. Grafted with DBBM alone and covered with collagen membrane (DBBM group), 3. Control group spontaneous healing. The area of the alveolar bone in center (C-), mesial (M-) and distal (D-) section was compared with preoperative in radiography. Bone cores were obtained for histopathology observation and comparison.ResultsIn C-, M- and D-section, the alveolar ridge area in all three groups was significantly reduced at 8 months postoperatively compared to the baseline (P < 0.05). The alveolar ridge area declines in the CGFs/DBBM group (C-12.75 ± 2.22 mm2, M-14.69 ± 2.82 mm2, D-16.95 ± 4.17 mm2) and DBBM group (C-14.08 ± 2.51 mm2, M-15.42 ± 3.47 mm2, D-16.09 ± 3.97 mm2) were non-significant differences. They were significantly less than the decline in the control group (C-45.04 ± 8.38 mm2 M-31.98 ± 8.34 mm2, D-31.85 ± 8.52 mm2) (P < 0.05). The percentage of newly formed bone in the CGFs/DBBM group (41.99 ± 12.99%) was significantly greater than that in DBBM group (30.68 ± 10.95%) (P < 0.05). The percentage of residual materials in the CGFs/DBBM group (16.19 ± 6.63%) was significantly less than that in the DBBM group (28.35 ± 11.70%) (P < 0.05).ConclusionCombined application of CGFs and DBBM effectively reduced the resorption of alveolar ridge and resulted in more newly formed bone than the use of DBBM with collagen membranes.
Highlights
Dental implants have gained popularity over time and are widely used to restore teeth
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The aim of the present study was to evaluate the clinical effects of concentrated growth factors (CGFs) combined with deproteinized bovine bone mineral (DBBM) for alveolar ridge preservation (ARP) in the maxillary molar area
Summary
Dental implants have gained popularity over time and are widely used to restore teeth. In cases of severe alveolar ridge resorption, complex bone augmentation surgery such as maxillary sinus lift is often indicated prior to the implant placement [5]. CGFs contain higher levels of growth factors, platelets, and cytokines than traditional platelet concentrates, such as platelet-rich plasma (PRP) and plateletrich fibrin (PRF). Due to their strong ability to promote tissue regeneration, CGFs have been widely used in the field of oral implants [10, 11]. In the current randomized controlled trial, a combination of CGFs and DBBM was applied to the extraction sites of maxillary molars to preserve the alveolar ridge. The aim of the present study was to evaluate the clinical effects of CGFs combined with DBBM for ARP in the maxillary molar area
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