Clinical application value of Ultrafast Pulse Wave Velocity in early cardiovascular injury of Immunoglobulin A nephropathy.

Abstract

To investigate the application and the related influencing factors of ultrafast pulse wave velocity (ufPWV) in theevaluation of carotid artery elasticity in patients with Immunoglobulin A nephropathy (IgAN). A totalof 156 IgAN patients and 50 healthy individuals were selected as the control group. The ufPWV technique was employed tomeasure carotid arterial elasticity parameters, including carotid intima-media thickness (cIMT), pulse wave velocity at thebeginning of systole (BS-PWV) and pulse wave velocity at the end of systole (ES-PWV). Across the three groups(control group, IgAN patients with normal renal function, and IgAN patients with renal dysfunction) there was an increasingtrend observed in cIMT, BS-PWV, and ES-PWV. Additionally, ES-PWV exhibited higher sensitivity than BS-PWV. Correlationanalysis revealed that BS-PWV and ES-PWV were positively correlated with age, body mass index (BMI), systolic bloodpressure (SBP), high-sensitivity C-reactive protein (hs-CRP), creatinine (Cr), blood urea nitrogen (BUN), and uric acid (UA)and negatively correlated with estimated glomerular filtration rate (eGFR). The ufPWV technique allows for therapid and direct measurement of arterial elasticity parameters in the neck and represents a novel approach for the early diagnosisand quantitative assessment of arterial stiffness risk in IgAN patients.