Clinical application value of thrombela-stogram for anticoagulant therapy to prevent deep venous thrombosis in perioperative period of Orthopedics Department

Abstract

Objective To research the clinical application effect of thrombela-stogram(TEG) for anticoagulant therapy to prevent deep venous thrombosis(DVT) in perioperative period of Orthopedics Department. Methods Sixty-eight cases of fracture patients treated with surgery in the Orthopedicsin Department of Jiangning Hospital of Nanjing were selected as the research subjects, and 42 healthy volunteers for a physical examination at the same period were selected as the control group.All fracture patients were treated with anticoagulant therapy after surgery, according to the different anticoagulants, the fracture patients were divided into the low molecular weight heparin(LWMH) group and the rivaroxaban group.On the day of the investigation, the control group was detected by TEG, and the TEG test was performed on all the patients during the perioperative period. Results There was no significant difference on the TEG test results between fracture patients and the control group(P>0.05), the TEG test results of fracture patients were normal, and the blood was not in the high coagulation state.On the 7th d of anticoagulant therapy and the end of anticoagulant therapy, the R value in the LWMH group and in the rivaroxaban group were the highest positive rate, were all more than 50%.At the end of the anticoagulant therapy, the abnormal detection rate of α angle, maximum thrombus(MA) and integrated coagulation index(CI) in the rivaroxaban group were 35.29%, 32.35%, 41.76%, respectively, were significantly higher than those in the LWMH group(8.82%, 17.65%, 11.76%), the differences were statistically significant(χ2=6.9283, 5.7566, 7.5556, P<0.05). After the end of the anticoagulant therapy for Doppler ultrasound, 9 cases were diagnosed as DVT, and the incidence rate was 14.06%.Compared and founded, at the end of the anti coagulation therapy, the great value of the diagnostic indicators were α angle, MA and CI, the sensitivity was 64.71%, 76.47%, 73.53% respectively, and the specificity was 79.41%, 73.53%, 82.35% respectively. Conclusion After fracture surgery, the coagulation function of the patients are changed, using TEG dynamic detection can accurately understand the change of blood state in real time, and it has important reference value for the evaluation of blood coagulation function.With MA was equal to 68.35 mm as a clinical diagnosis of critical point. Key words: Thrombela-stogram; Perioperative period of department of orthopedics; Anticoagulant therapy; Deep venous thrombosis