Abstract
The purpose of this article is to discuss the literature on the clinical role of the ocular fluorophotometer in different ocular conditions. The ocular fluorophotometer measures the fluorescent compounds present in the cornea, lens, vitreous body and retinal pigment epithelium. These compounds can be present naturally, known as autofluorescent, or fluorescent after application of fluorescein either topically or systemically. The fluorophotometer measures the changes in barrier function in both corneal epithelium and endothelium. It is a quantitative method of detecting a breakdown in the blood–ocular barriers. It helps to measure the inward and outward movements of fluorescein across the blood–retinal barrier as well as blood–aqueous barrier permeability. The measurement of ocular barrier permeability by the fluorophotometer helps to improve our understanding of ocular conditions. It is also useful to assess the effect specific therapeutic approaches in some diseases and clinical research.
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