Abstract
Intravenous immunoglobulin (IVIG) is safe and effective concentration formulation which is obtained from the plasma of health adults.Domestic IVIG was used in clinical since 1979 by Liao Qingkui, who are pediatric doctor form West China Second Hospital. Researches on clinical applications of IVIG are quickly developed at home and abroad, which now become the indispensable treatment for primary and secondary immunodeficiency diseases, autoimmune diseases, infectious disease(especially for virus), stem cell or organ transplantation and ICU areas.Treatment dose and course are administered accordding to individuals and pharmacokinetic characteristics of IVIG, immunoglobulin rose to peak of drug concentration quickly, and recovery to the original level of plasma after 3-4 weeks.Common therapeutic dose of IVIG recommended by the literature were 400 mg/(kg·per time), 3-5 d, or 1 000 mg/(kg·per time), 2 d, or 2 000 mg/(kg·per time), 1 d, which were usually used for idiopathic thrombocytopenic purpura, Kawasaki disease patients.Treatment perscription of 200-600 mg/(kg·per time), 1 d, and once every 2-6 weeks are used for immunodeficiency diseases and infections.Now, the clinical application of IVIG was reviewed. Key words: Intravenous infection; Immunoglobulin; Clinical application
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