Clinical application of CT guided percutaneous lung biopsy in the precise treatment of lung carcinoma

Abstract

Objective To investigate the clinical application of CT guided percutaneous lung biopsy in the precise treatment of lung carcinoma. Method All 73 Patients underwent CT-guided percutaneous lung biopsy from December, 2014 to June, 2016 Department of Respiratory Medicine, Second Affiliated Hospital of Xi′an Jiaotong University, and they was confirmed by pathology, treatment or follow-up. The best puncture and puncture points were selected according to CT scan images. Resulst All 73 cases of lung lesions were successfully sampled, and 39 cases of malignant tumor were indicated by pathology, and 34 cases were benign lesion. The diagnosis of malignancy tumors(42)and benign lesions(31)was confirmed by pathology, treatment or follow-up. The sensitivity of CT-guided percutaneous lung biopsy for malignancy was 92.9%(39/42), accuracy 95.9%(70/73), specificity100%(39/39). Epidermal growth factor receptor(EGFR) gene mutations were identified in 11 of 23(47.8%) biopsy samples of adenocarcinoma. In-frame deletions of exon 19 occurred in 4 patients(36.4%) and point mutation occurred at codon858(exon 21) in 3(27.3%). After puncture, there were 14 cases with mild and non-fatal adverse reactions. Conelusion CT-guided percutaneous lung biopsy is a safe, accurate, and effective method for diagnosis of chest lesions, it is important value in the diagnosis and treatment of lung disease. Key words: Bronchogenic carcinoma; CT-guided; Pulmonary puncture; Biopsy