Diagnostic value of lung biopsy through SPECT with CT-guided percutaneous paracentesis and tumor markers for peripheral lung cancer

Abstract

Objective To explore the diagnostic value of SPECT localization and CT-guided percutaneous lung biopsy and tumor markers in peripheral lung cancer. Methods A total of 275 patients with peripheral lung neoplasms were retrospectively analyzed. Pathological diagnosis was performed by SPECT with localizable CT-guided lung biopsy. The value of this imaging modality in combination with tumor markers in diagnosing lung cancer was evaluated. T-test or approximate t-test were used for data analysis using SPSS13.0 software. Results All of the lung biopsies were successful. The sensitivity, specificity, and accuracy for lung cancer diagnosis were 97.01%, 100%, and 97.82%, respectively. No significant difference in carcino-embryonic antigen and CYFRA21-1 values was detected between non-small-cell lung cancer and small-cell lung cancer(t=1.081, 0.666, both P>0.05). However, the neuron-specific enolase(NSE) value of small-cell lung cancer(SCLC) was significantly higher than that of non-small-cell lung cancer(NSCLC), and the difference was statistically significant(t=3.671, P<0.05). The area under the receiver operating curve of NSE was 0.935. The cut-off value of the diagnostic critical of NSE was 26.86 ng/mL, with a sensitivity of 91.34% and specificity of 84.92%. Conclusions SPECT with localizable CT-guided percutaneous lung biopsy is feasible and highly accurate for diagnosis of peripheral lung cancer. In addition, NSE is useful in the identification of SCLC and NSCLC. Key words: Tomography, emission-computed, single-phton; Tomography, X-ray computed; Lung carcinoma; Biopsy; Tumor markers