CLINICAL AND SUBCLINICAL FEATURES OF PEDIATRIC PATIENTS WITH HEPATOBLASTOMA AT NATIONAL CHILDREN HOSPITAL

Abstract

Background: Hepatoblastoma is the most common malignant liver tumor in children. Aims: Study on clinical and subclinical features of pediatric patients with hepatoblastoma at National Children Hospital from 1/2016 to 8/2019. Materials and Methods: A total patients with operated Hepatoblastoma diagnosed by pathologists, at the Viet Nam National Children’s Hospital from January 2016 to August 2019. The study design is retrospective. Resullts: Study subject’s mean of age was 36,8 months (range 4 – 149 months), the common group of age was under 5 years old (76,7%), male’s more than female (56,7% and 43,3%). The most common clinical symptoms were hepatomegaly (50%), a palpable abdominal mass (30%), abdominal pain (13,3%), secondary anemia (13,3%), weight loss (6,7%), jaundice (3,3%). About laboratory test: 83,3% patients with anemia, 36,7% patients with thrombocytosis, 90% patients with hight GOT levels, 53,3% patients with hight GPT levels, 96,7% patients with hight serum AFP levels and the average value of AFP was 217160,7 ng/ml (range 575 – 1686328,6 ng/ml). Mean size of the tumor on computerized tomography was 5,48cm (range 2 – 15cm), 60% size of tumor ≤ 5cm, 96,7% had only one tumor, 70% primary tumor located to the right lobe of the liver, 76,7% were staged PRETEXT II, the most common hepatoblastoma histopathological subtypes was as follows: epithelial (80%). Conclusion: Clinical symptoms of hepatoblastoma are usually nonspecific. A routine check – up strategy for early detection of hepatoblastoma and the role of subclinical aids in diagnosis is very important.